The amphioxus rab GDP-dissociation inhibitor (GDI) gene is neural- specific: implications for the evolution of chordate rab GDI genes
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چکیده
منابع مشابه
Mutant Prion Protein Expression Is Associated with an Alteration of the Rab GDP Dissociation Inhibitor (GDI)/Rab11 Pathway*□S
The prion protein (PrP) is a glycosylphosphatidylinositolanchored membrane glycoprotein that plays a vital role in prion diseases, a class of fatal neurodegenerative disorders of humans and animals. Approximately 20% of human prion diseases display autosomal dominant inheritance and are linked to mutations in the PrP gene on chromosome 20. PrP mutations are thought to favor the conformational c...
متن کاملIdentification of a GDI displacement factor that releases endosomal Rab GTPases from Rab-GDI.
Prenylated Rab GTPases occur in the cytosol in their GDP-bound conformations bound to a cytosolic protein termed GDP-dissociation inhibitor (GDI). Rab-GDI complexes represent a pool of active, recycling Rab proteins that can deliver Rabs to specific and distinct membrane-bound compartments. Rab delivery to cellular membranes involves release of GDI, and the membrane-associated Rab protein then ...
متن کاملStructural insights into the function of the Rab GDI superfamily.
The 1.81 A crystal structure of Rab GDP-dissociation inhibitor (GDI), a protein that plays a critical role in the recycling of Rab GTPases involved in membrane vesicular transport, has been recently determined. Biochemical studies implicate a highly conserved region involved in Rab binding, which is common to both GDI and the evolutionarily-related choroideremia gene product (CHM/REP) required ...
متن کاملRab GDP dissociation inhibitor as a general regulator for the membrane association of rab proteins.
Rab proteins comprise a family of small GTPases that serve a regulatory role in membrane traffic. These proteins are in part cytosolic and in part associated with the membranes of specific exocytic and endocytic organelles. Smg p25A/rab3A GDI, a cytosolic protein which inhibits the dissociation of GDP from smg p25A/rab3A, Sec4p, and rab11, has also been found to prevent association of rab3A wit...
متن کاملSearching for Signaling Balance through the Identification of Genetic Interactors of the Rab Guanine-Nucleotide Dissociation Inhibitor gdi-1
BACKGROUND The symptoms of numerous diseases result from genetic mutations that disrupt the homeostasis maintained by the appropriate integration of signaling gene activities. The relationships between signaling genes suggest avenues through which homeostasis can be restored and disease symptoms subsequently reduced. Specifically, disease symptoms caused by loss-of-function mutations in a parti...
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ژورنال
عنوان ژورنال: Molecular Biology and Evolution
سال: 1999
ISSN: 0737-4038,1537-1719
DOI: 10.1093/oxfordjournals.molbev.a026213